Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets
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چکیده
منابع مشابه
GMP-140 mediates adhesion of stimulated platelets to neutrophils.
In vivo, platelets associate with neutrophils at sites of hemorrhage or inflammation. In vitro, stimulated platelets bind to neutrophils in a Ca2(+)-dependent manner. GMP-140, an integral membrane glycoprotein found in secretory granules of platelets and endothelium, is rapidly translocated to the cell surface after cellular activation. It shares sequence similarity with two leukocyte adhesion ...
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1Hematology Oncology Centre, Qilu Hospital, Shandong University, Jinan, China; 2Yantai Yantaishan Hospital, Yantai, China; 3Department of General Medicine, Provincial Hospital, affiliated to Shandong University, Jinan, China; 4Medical College, Shandong University, Jinan, China; and 5Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Mini...
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Immune and inflammatory responses require leukocytes to migrate within and through the vasculature, a process that is facilitated by their capacity to switch to a polarized morphology with an asymmetric distribution of receptors. We report that neutrophil polarization within activated venules served to organize a protruding domain that engaged activated platelets present in the bloodstream. The...
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ژورنال
عنوان ژورنال: eLife
سال: 2019
ISSN: 2050-084X
DOI: 10.7554/elife.44031